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Comparative analysis of mutational robustness of the intrinsically disordered viral protein VPg and of its interactor eIF4E

Conformational intrinsic disorder is a feature present in many virus proteins. Intrinsically disordered regions (IDRs) have weaker structural requirement than ordered regions and mutations in IDRs could have a lower impact on the virus fitness. This could favor its exploration of adaptive solutions....

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Vydáno v:PLoS One
Hlavní autoři: Walter, Jocelyne, Charon, Justine, Hu, Yihua, Lachat, Joy, Leger, Thomas, Lafforgue, Guillaume, Barra, Amandine, Michon, Thierry
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6375565/
https://ncbi.nlm.nih.gov/pubmed/30763345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0211725
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