Low glucose and metformin-induced apoptosis of human ovarian cancer cells is connected to ASK1 via mitochondrial and endoplasmic reticulum stress-associated pathways

BACKGROUND: Metformin, a first-line drug for type 2 diabetes, could induce apoptosis in cancer cells. However, the concentration of glucose affects the effect of metformin, especially low glucose in the culture medium can enhance the cytotoxicity of metformin on cancer cells. Since mitochondria and...

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Veröffentlicht in:J Exp Clin Cancer Res
Hauptverfasser: Ma, Liwei, Wei, Jianwei, Wan, Junhu, Wang, Weiwei, Wang, Li, Yuan, Yongjie, Yang, Zijun, Liu, Xianzhi, Ming, Liang
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6375187/
https://ncbi.nlm.nih.gov/pubmed/30760281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1090-6
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