DNA demethylation is associated with malignant progression of lower-grade gliomas

To elucidate the mechanisms of malignant progression of lower-grade glioma, molecular profiling using methylation array, whole-exome sequencing, and RNA sequencing was performed for 122, 36 and 31 gliomas, respectively. This cohort included 24 matched pairs of initial lower-grade gliomas and recurre...

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Publicat a:Sci Rep
Autors principals: Nomura, Masashi, Saito, Kuniaki, Aihara, Koki, Nagae, Genta, Yamamoto, Shogo, Tatsuno, Kenji, Ueda, Hiroki, Fukuda, Shiro, Umeda, Takayoshi, Tanaka, Shota, Takayanagi, Shunsaku, Otani, Ryohei, Nejo, Takahide, Hana, Taijun, Takahashi, Satoshi, Kitagawa, Yosuke, Omata, Mayu, Higuchi, Fumi, Nakamura, Taishi, Muragaki, Yoshihiro, Narita, Yoshitaka, Nagane, Motoo, Nishikawa, Ryo, Ueki, Keisuke, Saito, Nobuhito, Aburatani, Hiroyuki, Mukasa, Akitake
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6374451/
https://ncbi.nlm.nih.gov/pubmed/30760837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-38510-0
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