Targeting autophagy potentiates antitumor activity of Met-TKIs against Met-amplified gastric cancer

Met tyrosine kinase inhibitors (Met-TKIs) subjected to ongoing clinical trials are a promising option for Met-amplified gastric cancer (GC), but how to optimize their antitumor activity especially with combination schemes remains unclear. Since autophagy is known to be initiated by Met-TKIs, we inve...

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Udgivet i:Cell Death Dis
Main Authors: Lin, Xiaoting, Peng, Zhi, Wang, Xiaojuan, Zou, Jianling, Chen, Dongshao, Chen, Zuhua, Li, Zhongwu, Dong, Bin, Gao, Jing, Shen, Lin
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6374362/
https://ncbi.nlm.nih.gov/pubmed/30760701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1314-x
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