Protein disulfide isomerase regulation by nitric oxide maintains vascular quiescence and controls thrombus formation

BACKGROUND: Protein disulfide isomerase (PDI) serves an essential role in thrombus formation and PDI inhibition is being evaluated clinically as a novel anticoagulant. Yet little is known about the regulation of PDI in the vasculature. Thiols within the catalytic motif of PDI are essential for its r...

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Publicado no:J Thromb Haemost
Main Authors: Bekendam, Roelof H., Iyu, David, Passam, Freda, Stopa, Jack D., De Ceunynck, Karen, Muse, Oluwatoyosi, Bendapudi, Pavan K., Garnier, Céline L., Gopal, Srila, Crescence, Lydie, Chiu, Joyce, Furie, Bruce, Panicot-Dubois, Laurence, Hogg, Philip J., Dubois, Christophe, Flaumenhaft, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6374154/
https://ncbi.nlm.nih.gov/pubmed/30207066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.14291
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