Genome analysis identifies a spontaneous nonsense mutation in ppsD leading to attenuation of virulence in laboratory-manipulated Mycobacterium tuberculosis

BACKGROUND: A previous laboratory study involving wild type, mutant and devR/dosR complemented strains of Mycobacterium tuberculosis reported the attenuation phenotype of complemented strain, Comp1. This phenotype was intriguing since the parental strain H37Rv, devR mutant (Mut1) and additional comp...

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Bibliographic Details
Published in:BMC Genomics
Main Authors: De Majumdar, Shyamasree, Sikri, Kriti, Ghosh, Payel, Jaisinghani, Neetika, Nandi, Malobi, Gandotra, Sheetal, Mande, Shekhar, Tyagi, Jaya Sivaswami
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6373159/
https://ncbi.nlm.nih.gov/pubmed/30755157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-019-5482-y
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