Dynamic inosinome profiles reveal novel patient stratification and gender-specific differences in glioblastoma

BACKGROUND: Adenosine-to-inosine (A-to-I) RNA editing is an essential post-transcriptional mechanism mediated by ADAR enzymes that have been recently associated with cancer. RESULTS: Here, we characterize the inosinome signature in normal brain and de novo glioblastoma (GBM) using new metrics that r...

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Vydáno v:Genome Biol
Hlavní autoři: Silvestris, Domenico Alessandro, Picardi, Ernesto, Cesarini, Valeriana, Fosso, Bruno, Mangraviti, Nicolò, Massimi, Luca, Martini, Maurizio, Pesole, Graziano, Locatelli, Franco, Gallo, Angela
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6373152/
https://ncbi.nlm.nih.gov/pubmed/30760294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-019-1647-x
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