Campylobacter jejuni enters gut epithelial cells and impairs intestinal barrier function through cleavage of occludin by serine protease HtrA

Campylobacter jejuni secretes HtrA (high temperature requirement protein A), a serine protease that is involved in virulence. Here, we investigated the interaction of HtrA with the host protein occludin, a tight junction strand component. Immunofluorescence studies demonstrated that infection of pol...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Gut Pathog
Main Authors: Harrer, Aileen, Bücker, Roland, Boehm, Manja, Zarzecka, Urszula, Tegtmeyer, Nicole, Sticht, Heinrich, Schulzke, Jörg D., Backert, Steffen
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2019
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6373145/
https://ncbi.nlm.nih.gov/pubmed/30805031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13099-019-0283-z
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