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Differential PI(4,5)P(2) sensitivities of TRPC4, C5 homomeric and TRPC1/4, C1/5 heteromeric channels
Transient receptor potential canonical (TRPC) 4 and TRPC5 channels are modulated by the Gα(q)-PLC pathway. Since phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) maintains TRPC4 and TRPC5 channel function, the Gα(q)-PLC pathway inhibits channel activity by depleting PI(4,5)P(2). Here we investiga...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6372716/ https://ncbi.nlm.nih.gov/pubmed/30755645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-38443-0 |
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