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Inhibition of upper small intestinal mTOR lowers plasma glucose levels by inhibiting glucose production

Glucose homeostasis is partly controlled by the energy sensor mechanistic target of rapamycin (mTOR) in the muscle and liver. However, whether mTOR in the small intestine affects glucose homeostasis in vivo remains unknown. Here, we first report that delivery of rapamycin or an adenovirus encoding t...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Waise, T. M. Zaved, Rasti, Mozhgan, Duca, Frank A., Zhang, Song-Yang, Bauer, Paige V., Rhodes, Christopher J., Lam, Tony K. T.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6372624/
https://ncbi.nlm.nih.gov/pubmed/30755615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08582-7
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