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Cotranslational assembly of protein complexes in eukaryotes revealed by ribosome profiling

The folding of newly synthesized proteins to the native state is a major challenge within the crowded cellular environment, as non-productive interactions can lead to misfolding, aggregation and degradation1. Cells cope with this challenge by coupling synthesis with polypeptide folding and by using...

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Publicado en:Nature
Main Authors: Shiber, Ayala, Döring, Kristina, Friedrich, Ulrike, Klann, Kevin, Merker, Dorina, Zedan, Mostafa, Tippmann, Frank, Kramer, Günter, Bukau, Bernd
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6372068/
https://ncbi.nlm.nih.gov/pubmed/30158700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0462-y
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