A phenome-wide association study to discover pleiotropic effects of PCSK9, APOB, and LDLR

We conducted an electronic health record (EHR)-based phenome-wide association study (PheWAS) to discover pleiotropic effects of variants in three lipoprotein metabolism genes PCSK9, APOB, and LDLR. Using high-density genotype data, we tested the associations of variants in the three genes with 1232...

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Publicado en:NPJ Genom Med
Main Authors: Safarova, Maya S., Satterfield, Benjamin A., Fan, Xiao, Austin, Erin E., Ye, Zhan, Bastarache, Lisa, Zheng, Neil, Ritchie, Marylyn D., Borthwick, Kenneth M., Williams, Marc S., Larson, Eric B., Scrol, Aaron, Jarvik, Gail P., Crosslin, David R., Leppig, Kathleen, Rasmussen-Torvik, Laura J., Pendergrass, Sarah A., Sturm, Amy C., Namjou, Bahram, Shah, Amy Sanghavi, Carroll, Robert J., Chung, Wendy K., Wei, Wei-Qi, Feng, QiPing, Stein, C. Michael, Roden, Dan M., Manolio, Teri A., Schaid, Daniel J., Denny, Joshua C., Hebbring, Scott J., de Andrade, Mariza, Kullo, Iftikhar J.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6370860/
https://ncbi.nlm.nih.gov/pubmed/30774981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41525-019-0078-7
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