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A mutation in the AdhE alcohol dehydrogenase of Clostridium thermocellum increases tolerance to several primary alcohols, including isobutanol, n-butanol and ethanol

Clostridium thermocellum is a good candidate organism for producing cellulosic biofuels due to its native ability to ferment cellulose, however its maximum biofuel titer is limited by tolerance. Wild type C. thermocellum is inhibited by 5 g/L n-butanol. Using growth adaptation in a chemostat, we inc...

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Publicat a:Sci Rep
Autors principals: Tian, Liang, Cervenka, Nicholas D., Low, Aidan M., Olson, Daniel G., Lynd, Lee R.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6370804/
https://ncbi.nlm.nih.gov/pubmed/30741948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-37979-5
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