HIF-1α-Deficiency in Myeloid Cells Leads to a Disturbed Accumulation of Myeloid Derived Suppressor Cells (MDSC) During Pregnancy and to an Increased Abortion Rate in Mice

Abortions are the most important reason for unintentional childlessness. During pregnancy, maternal immune cells are in close contact to cells of the semi-allogeneic fetus. Dysregulation of the maternal immune system leading to defective adaptation to pregnancy often plays a role in pathogenesis of...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Köstlin-Gille, Natascha, Dietz, Stefanie, Schwarz, Julian, Spring, Bärbel, Pauluschke-Fröhlich, Jan, Poets, Christian F., Gille, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6370686/
https://ncbi.nlm.nih.gov/pubmed/30804946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00161
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