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Deep Neural Network Models for Predicting Chemically Induced Liver Toxicity Endpoints From Transcriptomic Responses

Improving the accuracy of toxicity prediction models for liver injuries is a key element in evaluating the safety of drugs and chemicals. Mechanism-based information derived from expression (transcriptomic) data, in combination with machine-learning methods, promises to improve the accuracy and robu...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Wang, Hao, Liu, Ruifeng, Schyman, Patric, Wallqvist, Anders
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6370634/
https://ncbi.nlm.nih.gov/pubmed/30804783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00042
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