Novel mechanism of resistance to targeted therapies in lung cancer

We have identified a non-canonical role of0 Notch3 in response to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) therapy, whereby Notch3 associates with β-catenin, resulting in increased catenin beta-1 (CTNNB1, best known as β-catenin) stability and increased survival of dru...

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Bibliografiske detaljer
Udgivet i:Mol Cell Oncol
Main Authors: Wang, Walter, Carbone, David P., Arasada, Rajeswara Rao
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2018
Fag:
Commentary
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6370384/
https://ncbi.nlm.nih.gov/pubmed/30788420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2018.1551015
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