Chaperone activation and client binding of a 2-cysteine peroxiredoxin

Many 2-Cys-peroxiredoxins (2-Cys-Prxs) are dual-function proteins, either acting as peroxidases under non-stress conditions or as chaperones during stress. The mechanism by which 2-Cys-Prxs switch functions remains to be defined. Our work focuses on Leishmania infantum mitochondrial 2-Cys-Prx, whose...

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Publicado no:Nat Commun
Main Authors: Teixeira, Filipa, Tse, Eric, Castro, Helena, Makepeace, Karl A. T., Meinen, Ben A., Borchers, Christoph H., Poole, Leslie B., Bardwell, James C., Tomás, Ana M., Southworth, Daniel R., Jakob, Ursula
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6368585/
https://ncbi.nlm.nih.gov/pubmed/30737390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08565-8
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