Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy

Genomic changes observed across treatment may result from either clonal evolution or geographically disparate sampling of heterogeneous tumors. Here we use computational modeling based on analysis of fifteen primary breast tumors and find that apparent clonal change between two tumor samples can fre...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Caswell-Jin, Jennifer L., McNamara, Katherine, Reiter, Johannes G., Sun, Ruping, Hu, Zheng, Ma, Zhicheng, Ding, Jie, Suarez, Carlos J., Tilk, Susanne, Raghavendra, Akshara, Forte, Victoria, Chin, Suet-Feung, Bardwell, Helen, Provenzano, Elena, Caldas, Carlos, Lang, Julie, West, Robert, Tripathy, Debu, Press, Michael F., Curtis, Christina
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6368565/
https://ncbi.nlm.nih.gov/pubmed/30737380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08593-4
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