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Efficient long-term depletion of CD20(+) B cells by rituximab does not affect gut-resident plasma cells
The vast majority of antibody-producing B cells are located within the gastrointestinal tract and are key players in maintaining homeostasis. The failure of rituximab, a potent B cell–depleting agent, to ameliorate ulcerative colitis in a single clinical trial has dampened enthusiasm to study B cell...
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| Udgivet i: | Ann N Y Acad Sci |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6368409/ https://ncbi.nlm.nih.gov/pubmed/29291255 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nyas.13577 |
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