A mandatory role of nuclear PAK4-LIFR axis in breast-to-bone metastasis of ERα-positive breast cancer cells

The mechanism of estrogen receptor alpha (ERα)-positive breast cancer-associated bone metastasis is poorly understood. In this article, we report that nuclear p21-activated kinase 4 (nPAK4) is a novel repressor of ERα-mediated transactivation in a 17β-estradiol (E2)-dependent manner and promotes PAK...

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Publicat a:Oncogene
Autors principals: Li, Yanshu, Zhang, Hongyan, Zhao, Yue, Wang, Chunyu, Cheng, Zhenguo, Tang, Lina, Gao, Yunling, Liu, Furong, Li, Jiabin, Li, Yan, Li, Yang, Geng, Nanxi, Rui, Xue, Teng, Yuee, Liu, Yunpeng, Cao, Liu, Kumar, Rakesh, Jin, Feng, Li, Feng
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6367215/
https://ncbi.nlm.nih.gov/pubmed/30177834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0456-0
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