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Strategies for Efficient Genome Editing Using CRISPR-Cas9

The targetable DNA endonuclease CRISPR-Cas9 has transformed analysis of biological processes by enabling robust genome editing in model and nonmodel organisms. Although rules directing Cas9 to its target DNA via a guide RNA are straightforward, wide variation occurs in editing efficiency and repair...

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Bibliografische gegevens
Gepubliceerd in:Genetics
Hoofdauteurs: Farboud, Behnom, Severson, Aaron F., Meyer, Barbara J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Genetics Society of America 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6366907/
https://ncbi.nlm.nih.gov/pubmed/30504364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.118.301775
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