Electrical Abnormalities in Dopaminergic Neurons of the Substantia Nigra in Mice With an Aromatic L-Amino Acid Decarboxylase Deficiency

Aromatic L-acid decarboxylase (AADC) deficiency causes severe motor disturbances in affected children. A putamen-targeted gene therapy improves the motor function of patients. The present study investigated the electrical properties of dopaminergic (DA) neurons in the substantia nigra compacta (SNc)...

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Bibliographic Details
Published in:Front Cell Neurosci
Main Authors: Ho, Shih-Yin, Chien, Yin-Hsiu, Tsai, Li-Kai, Muramatsu, Shin-ichi, Hwu, Wuh-Liang, Liou, Horng-Huei, Lee, Ni-Chung
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6365702/
https://ncbi.nlm.nih.gov/pubmed/30766478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2019.00009
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