MT1-MMP Binds Membranes by Opposite Tips of its β-Propeller to Position it for Pericellular Proteolysis

Critical to migration of tumor cells and endothelial cells is the proteolytic attack of membrane type 1 matrix metalloproteinase (MT1-MMP) upon collagen, growth factors, and receptors at cell surfaces. Lipid bilayer interactions of the substrate-binding hemopexin-like (HPX) domain of MT1-MMP were in...

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Udgivet i:Structure
Main Authors: Marcink, Tara C., Simoncic, Jayce A., An, Bo, Knapinska, Anna M., Fulcher, Yan G., Akkaladevi, Narahari, Fields, Gregg B., Van Doren, Steven R.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6365218/
https://ncbi.nlm.nih.gov/pubmed/30471921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2018.10.008
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