PCSK9 loss-of-function variants and risk of infection and sepsis in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort

BACKGROUND: Elevated proprotein convertase subtilisin/kexin type 9 (PCSK9) levels have been associated with adverse outcomes in patients hospitalized for sepsis. PCSK9 loss-of-function (LOF) variants area associated with lower low-density lipoprotein cholesterol (LDL-C) levels. Decreased LDL-C is a...

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Pubblicato in:PLoS One
Autori principali: Mitchell, Kellie A., Moore, Justin Xavier, Rosenson, Robert S., Irvin, Ryan, Guirgis, Faheem W., Shapiro, Nathan, Safford, Monika, Wang, Henry E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6364964/
https://ncbi.nlm.nih.gov/pubmed/30726226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0210808
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