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Nontherapeutic equivalence of a generic product of imipenem-cilastatin is caused more by chemical instability of the active pharmaceutical ingredient (imipenem) than by its substandard amount of cilastatin

BACKGROUND: We demonstrated therapeutic nonequivalence of “bioequivalent” generics for meropenem, but there is no data with generics of other carbapenems. METHODS: One generic product of imipenem-cilastatin was compared with the innovator in terms of in vitro susceptibility testing, pharmaceutical e...

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Publicat a:PLoS One
Autors principals: Agudelo, Maria, Rodriguez, Carlos A., Zuluaga, Andres F., Vesga, Omar
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6364906/
https://ncbi.nlm.nih.gov/pubmed/30726248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0211096
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