A Supramolecular Vaccine Platform Based on α-Helical Peptide Nanofibers

A supramolecular peptide vaccine system was designed in which epitope-bearing peptides self-assemble into elongated nanofibers composed almost entirely of alpha-helical structure. The nanofibers were readily internalized by antigen presenting cells and produced robust antibody, CD4+ T-cell, and CD8+...

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Udgivet i:ACS Biomater Sci Eng
Main Authors: Wu, Yaoying, Norberg, Pamela K., Reap, Elizabeth A., Congdon, Kendra L., Fries, Chelsea N., Kelly, Sean H., Sampson, John H., Conticello, Vincent P., Collier, Joel H.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6364304/
https://ncbi.nlm.nih.gov/pubmed/30740520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsbiomaterials.7b00561
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