Mapping the pH Sensors Critical for Host Cell Entry by a Complex Nonenveloped Virus

Bluetongue virus (BTV), in the family Reoviridae, is an insect-borne, double-capsid virus causing hemorrhagic disease in livestock around the world. Here, we elucidate how outer capsid proteins VP2 and VP5 coordinate cell entry of BTV. To identify key functional residues, we used atomic-level struct...

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Bibliographic Details
Published in:J Virol
Main Authors: Wu, Weining, Celma, Cristina C., Kerviel, Adeline, Roy, Polly
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2019
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6363992/
https://ncbi.nlm.nih.gov/pubmed/30518645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01897-18
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