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Oxidative Stress Induces Release of 2’-AMP from Microglia

BACKGROUND: Microglia metabolize exogenous 2’-AMP and 3’-AMP (non-canonical nucleotides) to adenosine and exogenous 2’-AMP and 3’-AMP (via conversion to adenosine) inhibit the production of inflammatory cytokines by microglia. This suggests that if microglia release endogenous 2’-AMP and/or 3’-AMP i...

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Bibliografiske detaljer
Udgivet i:Brain Res
Main Authors: Jackson, Travis C., Kotermanski, Shawn E., Kochanek, Patrick M., Jackson, Edwin K.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6363863/
https://ncbi.nlm.nih.gov/pubmed/30395838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2018.11.002
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