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Chromogranin A, the major lumenal protein in chromaffin granules, controls fusion pore expansion

Upon fusion of the secretory granule with the plasma membrane, small molecules are discharged through the immediately formed narrow fusion pore, but protein discharge awaits pore expansion. Recently, fusion pore expansion was found to be regulated by tissue plasminogen activator (tPA), a protein pre...

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Detalhes bibliográficos
Publicado no:J Gen Physiol
Main Authors: Abbineni, Prabhodh S., Bittner, Mary A., Axelrod, Daniel, Holz, Ronald W.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6363410/
https://ncbi.nlm.nih.gov/pubmed/30504267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201812182
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