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Proposed mechanism for the length dependence of the force developed in maximally activated muscles

The molecular bases of the Frank-Starling law of the heart and of its cellular counterpart, the length dependent activation (LDA), are largely unknown. However, the recent discovery of the thick filament activation, a second pathway beside the well-known calcium mediated thin filament activation, is...

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Detalles Bibliográficos
Publicado en:Sci Rep
Main Authors: Marcucci, Lorenzo, Washio, Takumi, Yanagida, Toshio
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6362285/
https://ncbi.nlm.nih.gov/pubmed/30718530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36706-4
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