The methylome of the celiac intestinal epithelium harbours genotype-independent alterations in the HLA region

The Human Leucocyte Antigen (HLA) locus and other DNA sequence variants identified in Genome-Wide Association (GWA) studies explain around 50% of the heritability of celiac disease (CD). However, the pathogenesis of CD could be driven by other layers of genomic information independent from sequence...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Fernandez-Jimenez, Nora, Garcia-Etxebarria, Koldo, Plaza-Izurieta, Leticia, Romero-Garmendia, Irati, Jauregi-Miguel, Amaia, Legarda, Maria, Ecsedi, Szilvia, Castellanos-Rubio, Ainara, Cahais, Vincent, Cuenin, Cyrille, Degli Esposti, Davide, Irastorza, Iñaki, Hernandez-Vargas, Hector, Herceg, Zdenko, Bilbao, Jose Ramon
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6362130/
https://ncbi.nlm.nih.gov/pubmed/30718669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-37746-6
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