The CENP-A centromere targeting domain facilitates H4K20 monomethylation in the nucleosome by structural polymorphism

Centromeric nucleosomes are composed of the centromere-specific histone H3 variant CENP-A and the core histones H2A, H2B, and H4. To establish a functional kinetochore, histone H4 lysine-20 (H4K20) must be monomethylated, but the underlying mechanism has remained enigmatic. To provide structural ins...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Arimura, Yasuhiro, Tachiwana, Hiroaki, Takagi, Hiroki, Hori, Tetsuya, Kimura, Hiroshi, Fukagawa, Tatsuo, Kurumizaka, Hitoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6362020/
https://ncbi.nlm.nih.gov/pubmed/30718488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08314-x
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