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Modeling spinocerebellar ataxias 2 and 3 with iPSCs reveals a role for glutamate in disease pathology
Spinocerebellar ataxias 2 and 3 (SCA2 and SCA3) are dominantly inherited neurodegenerative diseases caused by expansion of polyglutamine-encoding CAG repeats in the affected genes. The etiology of these disorders is known to involve widespread loss of neuronal cells in the cerebellum, however, the m...
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| 出版年: | Sci Rep |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6361947/ https://ncbi.nlm.nih.gov/pubmed/30718627 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-37774-2 |
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