Llwytho...
Efficient cross-trait penalized regression increases prediction accuracy in large cohorts using secondary phenotypes
We introduce cross-trait penalized regression (CTPR), a powerful and practical approach for multi-trait polygenic risk prediction in large cohorts. Specifically, we propose a novel cross-trait penalty function with the Lasso and the minimax concave penalty (MCP) to incorporate the shared genetic eff...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Nat Commun |
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| Prif Awduron: | , , , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
Nature Publishing Group UK
2019
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6361917/ https://ncbi.nlm.nih.gov/pubmed/30718517 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08535-0 |
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