CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary

Inactivating mutations in SMARCA4 (BRG1), a key SWI/SNF chromatin remodelling gene, underlie small cell carcinoma of the ovary, hypercalcemic type (SCCOHT). To reveal its druggable vulnerabilities, we perform kinase-focused RNAi screens and uncover that SMARCA4-deficient SCCOHT cells are highly sens...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Xue, Yibo, Meehan, Brian, Macdonald, Elizabeth, Venneti, Sriram, Wang, Xue Qing D., Witkowski, Leora, Jelinic, Petar, Kong, Tim, Martinez, Daniel, Morin, Geneviève, Firlit, Michelle, Abedini, Atefeh, Johnson, Radia M., Cencic, Regina, Patibandla, Jay, Chen, Hongbo, Papadakis, Andreas I., Auguste, Aurelie, de Rink, Iris, Kerkhoven, Ron M., Bertos, Nicholas, Gotlieb, Walter H., Clarke, Blaise A., Leary, Alexandra, Witcher, Michael, Guiot, Marie-Christine, Pelletier, Jerry, Dostie, Josée, Park, Morag, Judkins, Alexander R., Hass, Ralf, Levine, Douglas A., Rak, Janusz, Vanderhyden, Barbara, Foulkes, William D., Huang, Sidong
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2019
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6361890/
https://ncbi.nlm.nih.gov/pubmed/30718512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06958-9
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