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Phosphorylation status at Smad3 linker region modulates transforming growth factor‐β‐induced epithelial‐mesenchymal transition and cancer progression

Smad3, a major transcription factor in transforming growth factor‐β (TGF‐β) signaling, plays critical roles in both tumor‐suppressive and pro‐oncogenic functions. Upon TGF‐β stimulation, the C‐terminal tail of Smad3 undergoes phosphorylation that is essential for canonical TGF‐β signaling. The Smad3...

詳細記述

保存先:
書誌詳細
出版年:Cancer Sci
主要な著者: Ooshima, Akira, Park, Jinah, Kim, Seong‐Jin
フォーマット: Artigo
言語:Inglês
出版事項: John Wiley and Sons Inc. 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6361575/
https://ncbi.nlm.nih.gov/pubmed/30589983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13922
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