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Phosphorylation status at Smad3 linker region modulates transforming growth factor‐β‐induced epithelial‐mesenchymal transition and cancer progression
Smad3, a major transcription factor in transforming growth factor‐β (TGF‐β) signaling, plays critical roles in both tumor‐suppressive and pro‐oncogenic functions. Upon TGF‐β stimulation, the C‐terminal tail of Smad3 undergoes phosphorylation that is essential for canonical TGF‐β signaling. The Smad3...
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| 出版年: | Cancer Sci |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
John Wiley and Sons Inc.
2019
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6361575/ https://ncbi.nlm.nih.gov/pubmed/30589983 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13922 |
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