Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases

Members of the Flaviviridae family constitute a severe risk to human health. Whilst effective drugs have been developed against the hepacivirus HCV, no antiviral therapy is currently available for any other viruses, including the flaviviruses dengue (DENV), West Nile and Zika viruses. The RNA-depend...

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Detalles Bibliográficos
Publicado en:Biol Open
Autores principales: Riccio, Federica, Talapatra, Sandeep K., Oxenford, Sally, Angell, Richard, Mazzon, Michela, Kozielski, Frank
Formato: Artigo
Lenguaje:Inglês
Publicado: The Company of Biologists Ltd 2019
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6361211/
https://ncbi.nlm.nih.gov/pubmed/30602529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.037663
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