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Methotrexate Mechanism in Treatment of Rheumatoid Arthritis

Methotrexate has been used in treatment of rheumatoid arthritis (RA) since the 1980s and to this day is often the first line medication for RA treatment. In this review, we examine multiple hypotheses to explain the mechanism of methotrexate efficacy in RA. These include folate antagonism, adenosine...

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Detalhes bibliográficos
Publicado no:Joint Bone Spine
Main Authors: Friedman, Benjamin, Cronstein, Bruce
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6360124/
https://ncbi.nlm.nih.gov/pubmed/30081197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbspin.2018.07.004
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