Heterologous phosphoketolase expression redirects flux towards acetate, perturbs sugar phosphate pools and increases respiratory demand in Saccharomyces cerevisiae

INTRODUCTION: Phosphoketolases (Xfpk) are a non-native group of enzymes in yeast, which can be expressed in combination with other metabolic enzymes to positively influence the yield of acetyl-CoA derived products by reducing carbon losses in the form of CO(2). In this study, a yeast strain expressi...

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Détails bibliographiques
Publié dans:Microb Cell Fact
Auteurs principaux: Bergman, Alexandra, Hellgren, John, Moritz, Thomas, Siewers, Verena, Nielsen, Jens, Chen, Yun
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2019
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6359841/
https://ncbi.nlm.nih.gov/pubmed/30709397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-019-1072-6
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