Intranasal Delivery of Genistein-Loaded Nanoparticles as a Potential Preventive System against Neurodegenerative Disorders

Genistein has been reported to have antioxidant and neuroprotective activity. Despite encouraging in vitro and in vivo results, several disadvantages such as poor water solubility, rapid metabolism, and low oral bioavailability limit the clinical application of genistein. The aim of this study was t...

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Publicado en:Pharmaceutics
Autores principales: Rassu, Giovanna, Porcu, Elena Piera, Fancello, Silvia, Obinu, Antonella, Senes, Nina, Galleri, Grazia, Migheli, Rossana, Gavini, Elisabetta, Giunchedi, Paolo
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6359056/
https://ncbi.nlm.nih.gov/pubmed/30597930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics11010008
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