Mercaptopurine versus placebo to prevent recurrence of Crohn's disease after surgical resection (TOPPIC): a multicentre, double-blind, randomised controlled trial

BACKGROUND: Up to 60% of patients with Crohn's disease need intestinal resection within the first 10 years of diagnosis, and postoperative recurrence is common. We investigated whether mercaptopurine can prevent or delay postoperative clinical recurrence of Crohn's disease. METHODS: We did...

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Pubblicato in:Lancet Gastroenterol Hepatol
Autori principali: Mowat, Craig, Arnott, Ian, Cahill, Aiden, Smith, Malcolm, Ahmad, Tariq, Subramanian, Sreedhar, Travis, Simon, Morris, John, Hamlin, John, Dhar, Anjan, Nwokolo, Chuka, Edwards, Cathryn, Creed, Tom, Bloom, Stuart, Yousif, Mohamed, Thomas, Linzi, Campbell, Simon, Lewis, Stephen J, Sebastian, Shaji, Sen, Sandip, Lal, Simon, Hawkey, Chris, Murray, Charles, Cummings, Fraser, Goh, Jason, Lindsay, James O, Arebi, Naila, Potts, Lindsay, McKinley, Aileen J, Thomson, John M, Todd, John A, Collie, Mhairi, Dunlop, Malcolm G, Mowat, Ashley, Gaya, Daniel R, Winter, Jack, Naismith, Graham D, Ennis, Holly, Keerie, Catriona, Lewis, Steff, Prescott, Robin J, Kennedy, Nicholas A, Satsangi, Jack
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier B.V 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6358144/
https://ncbi.nlm.nih.gov/pubmed/28404197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S2468-1253(16)30078-4
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