Demonstrating vaccine effectiveness during a waning epidemic: A WHO/NIH meeting report on approaches to development and licensure of Zika vaccine candidates

Since its peak in early 2016, the incidence of Zika virus (ZIKV) cases has declined to such low levels that Phase 3 field efficacy trials may be infeasible. While great progress was made to rapidly advance several vaccine candidates into Phase 1 and 2 clinical trials, in the absence of sustained vir...

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Publicado en:Vaccine
Main Authors: Vannice, Kirsten S., Cassetti, M. Cristina, Eisinger, Robert W., Hombach, Joachim, Knezevic, Ivana, Marston, Hilary D., Wilder-Smith, Annelies, Cavaleri, Marco, Krause, Philip R.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier Science 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6357529/
https://ncbi.nlm.nih.gov/pubmed/30639461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2018.12.040
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