Identification of exon skipping events associated with Alzheimer’s disease in the human hippocampus

BACKGROUND: At least 90% of human genes are alternatively spliced. Alternative splicing has an important function regulating gene expression and miss-splicing can contribute to risk for human diseases, including Alzheimer’s disease (AD). METHODS: We developed a splicing decision model as a molecular...

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Detalles Bibliográficos
Publicado en:BMC Med Genomics
Main Authors: Han, Seonggyun, Miller, Jason E., Byun, Seyoun, Kim, Dokyoon, Risacher, Shannon L., Saykin, Andrew J., Lee, Younghee, Nho, Kwangsik
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2019
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6357347/
https://ncbi.nlm.nih.gov/pubmed/30704480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12920-018-0453-8
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