Modulation of RAB7A Protein Expression Determines Resistance to Cisplatin through Late Endocytic Pathway Impairment and Extracellular Vesicular Secretion

Background: Cisplatin (CDDP) is widely used in treatment of cancer, yet patients often develop resistance with consequent therapeutical failure. In CDDP-resistant cells alterations of endocytosis and lysosomal functionality have been revealed, although their causes and contribution to therapy respon...

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Vydáno v:Cancers (Basel)
Hlavní autoři: Guerra, Flora, Paiano, Aurora, Migoni, Danilo, Girolimetti, Giulia, Perrone, Anna Myriam, De Iaco, Pierandrea, Fanizzi, Francesco Paolo, Gasparre, Giuseppe, Bucci, Cecilia
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6357196/
https://ncbi.nlm.nih.gov/pubmed/30626032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11010052
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