A Triple Amino Acid Substitution at Position 88/94/95 in Glycoprotein GP2a of Type 1 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV1) Is Responsible for Adaptation to MARC-145 Cells

The Meat Animal Research Center-145 (MARC-145) cell line has been proven to be valuable for viral attenuation regarding vaccine development and production. Cell-adaptation is necessary for the efficient replication of porcine reproductive and respiratory syndrome virus (PRRSV) in these cells. Multip...

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Veröffentlicht in:Viruses
Hauptverfasser: Xie, Jiexiong, Trus, Ivan, Oh, Dayoung, Kvisgaard, Lise K., Rappe, Julie C. F., Ruggli, Nicolas, Vanderheijden, Nathalie, Larsen, Lars E., Lefèvre, François, Nauwynck, Hans J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6356402/
https://ncbi.nlm.nih.gov/pubmed/30626009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v11010036
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