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Metformin Impairs Glutamine Metabolism and Autophagy in Tumour Cells
Metformin has been shown to inhibit glutaminase (GLS) activity and ammonia accumulation thereby reducing the risk of hepatic encephalopathy in type 2 diabetic patients. Since tumour cells are addicted to glutamine and often show an overexpression of glutaminase, we hypothesize that the antitumoral m...
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| Pubblicato in: | Cells |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
MDPI
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6356289/ https://ncbi.nlm.nih.gov/pubmed/30646605 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8010049 |
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