Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathway

BACKGROUND: Hepatocellular carcinoma (HCC) is an aggressive malignant disease with poor prognosis. Recent advances suggest the existence of cancer stem cells (CSCs) within liver cancer, which are considered to be responsible for tumor relapse, metastasis, and chemoresistance. However, novel therapeu...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:EBioMedicine
Main Authors: Li, Binghua, Cao, Yajuan, Meng, Gang, Qian, Liyuan, Xu, Tiancheng, Yan, Chen, Luo, Ouyang, Wang, Shaohe, Wei, Jiwu, Ding, Yitao, Yu, Decai
פורמט: Artigo
שפה:Inglês
יצא לאור: Elsevier 2018
נושאים:
Research paper
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355660/
https://ncbi.nlm.nih.gov/pubmed/30555042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.11.063
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