Inhibition of AZIN2-sv induces neovascularization and improves prognosis after myocardial infarction by blocking ubiquitin-dependent talin1 degradation and activating the Akt pathway

BACKGROUND: We previously found that loss of lncRNA-AZIN2 splice variant (AZIN2-sv) increases cardiomyocyte (CM) proliferation and attenuates adverse ventricular remodelling post-myocardial infarction (MI). However, whether inhibition of AZIN2-sv can simultaneously induce angiogenesis and thus impro...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Li, Xinzhong, Sun, Yili, Huang, Senlin, Chen, Yanmei, Chen, Xiaoqiang, Li, Mengsha, Si, Xiaoyun, He, Xiang, Zheng, Hao, Zhong, Lintao, Yang, Yang, Liao, Wangjun, Liao, Yulin, Chen, Guojun, Bin, Jianping
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
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Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355659/
https://ncbi.nlm.nih.gov/pubmed/30545799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.12.001
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