High-Dosage Cefazolin Achieves Sufficient Cerebrospinal Diffusion To Treat an External Ventricular Drainage-Related Staphylococcus aureus Ventriculitis

A patient received continuous infusion of cefazolin 10 g then 8 g daily for an external ventricular drainage-related methicillin-susceptible Staphylococcus aureus (MSSA) ventriculitis. Median free concentrations in the cerebrospinal fluid were 11.9 and 6.1 mg/liter after 10- and 8-g doses, respectiv...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Grégoire, Matthieu, Gaborit, Benjamin, Deschanvres, Colin, Lecomte, Raphaël, Deslandes, Guillaume, Dailly, Éric, Ambrosi, Xavier, Bellouard, Ronan, Asseray, Nathalie, Lakhal, Karim, Boutoille, David
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2019
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355608/
https://ncbi.nlm.nih.gov/pubmed/30420481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01844-18
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