Identification of a Novel Gene Associated with High-Level β-Lactam Resistance in Heterogeneous Vancomycin-Intermediate Staphylococcus aureus Strain Mu3 and Methicillin-Resistant S. aureus Strain N315

β-Lactam resistance levels vary among methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates, mediated by chromosomal mutations and exogenous resistance gene mecA. However, MRSA resistance mechanisms are incompletely understood. A P440L mutation in the RNA polymerase β′ subunit (RpoC)...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Matsuo, Miki, Yamamoto, Norio, Hishinuma, Tomomi, Hiramatsu, Keiichi
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2019
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355590/
https://ncbi.nlm.nih.gov/pubmed/30455230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00712-18
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